A girl in the US born with HIV appears to have been cured
after very early treatment with standard drug therapy, researchers say.
The Mississippi child is now two-and-a-half years old and has
been off medication for about a year with no signs of infection.
More testing needs to be done to see if the treatment would have
the same effect on other children.
But the results could possibly lead to a cure for children with
HIV.
If the child stays healthy it would be only the world's second
reported cure.
Dr Deborah Persaud, a virologist at Johns Hopkins University in
Baltimore, presented the findings at the Conference on Retroviruses and
Opportunistic Infections in Atlanta.
"This is a proof of concept that HIV can be potentially
curable in infants," she said.
In 2007, Timothy Ray Brown became the first person in the world
believed to have recovered from HIV.
His infection was eradicated through an elaborate treatment for
leukaemia that involved the destruction of his immune system and a stem cell
transplant from a donor with a rare genetic mutation that resists HIV
infection.
In contrast, the case of the Mississippi baby involved a
cocktail of widely available drugs already used to treat HIV infection in
infants.
It suggests the treatment wiped out HIV before it could form
hideouts in the body.
These so-called reservoirs of dormant cells usually rapidly
re-infect anyone who stops medication, said Dr Persaud.
The baby girl was born in a rural hospital where her mother had
only just tested positive for HIV infection.
Because the mother had not been given any prenatal HIV
treatment, doctors knew the baby was at high risk of being infected.
Researchers said the baby was then transferred to the University
of Mississippi Medical Center in Jackson.
Once there, paediatric HIV specialist Dr Hannah Gay put the
infant on a cocktail of three standard HIV-fighting drugs when she was just 30
hours old, even before laboratory tests came back confirming her infection.
"I
just felt like this baby was at higher-than-normal risk and deserved our best
shot," Dr Gay said.
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